Richard “Dick” McCarthy is a very active senior. At 83, the Vermont native still loves to play pickleball, ride his bicycle, swim and golf. The retired history teacher and soccer coach has paid a price for his activity and longevity. For years, he battled the agony of arthritis in his knees.
“I had an aching pain in both of my knees,” he confirms. Dick was diagnosed by his physician with osteoarthritis, which is the wear-and-tear type that generally occurs with age. Along with the destruction of the cushioning cartilage in the joints typical of osteoarthritis, the lubricating fluid, called synovial fluid, also begins to thin over time. “Over the past four years, my orthopedic surgeon has given me synthetic synovial fluid shots into my knees,” shares Dick. “The first time he gave me the injections, the pain relief lasted about two years. The second time, it lasted probably six months. Then, in October of last year, I had the injections done again, and that lasted three months. They just weren’t doing the job."
“RegenMax is a proprietary formulation of the highest-quality stem cells, platelets and other bioactive growth factors,” describes Jason. “The cells and growth factors work together to stimulate healing in an arthritic or injured joint. “Dick was an active senior, and was having significant pain due to bone-on-bone degenerative arthritis. He was looking for nonsurgical treatment options that would substantially reduce his pain so he could continue doing his activities. We treated him with RegenMax Injection Therapy, and he like most patients had a very positive response.”
Zeke Motta knows better than just about anyone how playing football can affect the body. He was one of the best tacklers in the country during his football career. In High School, he was named first-team Class 6A all-state as a senior and was rated the No. 5 outside linebacker in nation. He chose to attend Notre Dame over many other schools and played in the 2013 National Title game where he led the game in tackles with 16 tackles! He was then drafted in NFL by the Atlanta Falcons where he unfortunately sustained career ending injuries.
"Over many years of high impact collisions my knee was in bad pain. I then hyper extended it and it didn’t feel or function normally. I am a very active person and I could no longer do the activities nor play the sports I wanted to,” Zeke stated. “After some research, I was fortunate enough to find the Regenerative Biologics Institute (RBI) where they offer the RegenMax Injection Therapy. The RegenMax scientists and physicians thoroughly explained the treatment to me which made perfect sense. I was going to use my own body to heal myself instead of having to undergo another more invasive surgery,” he added.
“The RegenMax procedure was definitely a unique experience for me as I was use to more invasive surgeries where they put me under but with this I was awake the whole time,” Zeke said. “Since receiving the therapy, I have made a tremendous improvement. I was even able to play soccer the other day and I was back to playing at 100%. As the weeks after the stem cell treatment progressed, I felt more and more strength in my knee, my mobility has increased and the pain has certainly diminished. I will absolutely be considering the RegenMax Injection Therapy for other orthopedic issues and definitely prior to any more surgeries.”
In the phase I safety trial, a single injection of adipose tissue derived stem cells into the knee patients was safe and well tolerated.
The stem cell treatment also showed durable and clinically meaningful pain relief in patients with knee osteoarthritis.
Examination of knee joint structure by MRI showed a statistically significant improvement in lateral tibial cartilage volume for patients treated with the stem cells. This result compared to a worsening in volume in placebo patients.
The research showed the stem cells work by secreting cytokines, growth factors and exosomes that act in concert to reduce inflammation and pain, and encourage accelerated healing and repair of damaged or diseased tissue.
A total of 1128 patients underwent standard liposuction under local anesthesia and SVF cells were isolated and prepared for application into 1-4 large joints. A total of 1856 joints, mainly knee and hip joints, were treated with a single dose of SVF cells. 1114 patients were followed for 12.1-54.3 months (median 17.2 months) for safety and efficacy.
No serious side effects, systemic infection or cancer was associated with SVF cell therapy. Most patients gradually improved 3-12 months after the treatment. At least 75% Score improvement was noticed in 63% of patients and at least 50% Score improvement was documented in 91% of patients 12 months after SVF cell therapy. Obesity and higher grade of OA were associated with slower healing. In conclusion, here we report a novel and promising treatment approach for patients with degenerative OA that is safe, cost-effective, and relying only on autologous cells.
X-ray's on some of the patients 12 months after stem cell therapy showed a widening of the joint space [arrows in picture to left], most likely due to greater cartilage volume.
This particular X-ray is from a 56 year old man with right knee grade 3 osteoarthritis and kissing bone phenomena in medial compartment.
Many of the traditional procedures people undergo to counter chronic knee pain in the hopes of avoiding a knee replacement have limited or no evidence to support them. Serious questions are now being raised about the benefits of the arthroscopic procedures that millions of people endure in hopes of delaying, if not avoiding, total knee replacements.
The latest challenge, published in May in BMJ by an expert panel that systematically reviewed 12 well-designed trials and 13 observational studies, concluded that arthroscopic surgery for degenerative knee arthritis and meniscal tears resulted in no lasting pain relief or improved function.
Three months after the procedure, fewer than 15 percent of patients experienced at best “a small or very small improvement in pain and function,” effects that disappeared completely within a year.
Other common interventions include steroid injections into the knee. These can reduce painful inflammation, but if used repeatedly, steroids can speed the development of arthritis in the joint. A study published in May in JAMA by researchers at Tufts Medical Center found that the injection of a corticosteroid every three months over two years resulted in greater loss of knee cartilage and no significant difference in knee pain compared to patients who received a placebo injection.
Stromal cells and pericytes release Growth Factors (GF’s) that promote cell division.
Therapies containing high WBC counts have been shown to inhibit a tissues ability to heal.
ANAHEIM, Calif. -- Garrett Richards is expected to be ready for spring training after the Los Angeles Angels right-hander completed his instructional league work with no problems in his right elbow. Richards had a platelet-rich plasma injection on Friday, the Angels announced. Richards also was examined by Dr. Steve Yoon, who saw continued healing in the pitcher's partially torn elbow ligament.
Richards avoided Tommy John surgery with rest, stem-cell therapy and PRP injections. He completed three instructional league outings this month with no setbacks.
Miami Dolphins center Mike Pouncey underwent a stem cell procedure as part of his recovery from a season-ending hip injury, the Palm Beach Post's Joe Schad reported Monday.
According to ESPN.com's James Walker, Pouncey's rehab is progressing as expected and that Dolphins head coach Adam Gase expects to have Pouncey healthy for the first week of the regular season.
Boston Celtics All-Star point guard Isaiah Thomas received a Platelet-Rich Plasma, or PRP, injection for a groin strain. Thomas said, "I'm going to do whatever I can to get back out there on the court. It's eating me alive to not be able to participate, not to be able to play, but I gotta be smart about this because I don't want this to linger on for the rest of the season. I gotta do what is best for my body."
OAKLAND, Calif. -- Starting point guard D'Angelo Russell will miss at least two weeks after receiving a platelet-rich plasma injection in his sore left knee, the Los Angeles Lakers announced Wednesday. Dr. Steve Yoon performed the procedure in Los Angeles. The Lakers said Russell will be re-evaluated in one week. Lakers coach Luke Walton said he didn't think Russell would need surgery.
Detroit Red Wings defenseman Niklas Kronwall sought out stem cell therapy in an effort to ameliorate the damage to his left knee. Kronwall revealed the treatment Saturday as he spoke about having played in his 800th career NHL game the previous night. The past two seasons have seen the veteran play on a permanently damaged knee. There is nothing surgically that can be done to alleviate the pain.
“Once you get bone-on-bone, at least all the research that is out there, it seems there is not too many things that you can do without having to jeopardize your career,” Kronwall said. “So you find a way through it.”
Cutting-edge techniques that harness the body’s natural regenerative power can help soldiers recover from traumatic injuries. This technique, termed interventional orthopedics, is minimally invasive and can replace surgery or speed the healing process after surgery—sometimes cutting recovery time from months to just weeks.